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KMID : 0380620230550030220
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Korean Journal of Food Science and Technology
2023 Volume.55 No. 3 p.220 ~ p.228
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Inhibitory effect of lamb placenta peptide powder on melanogenesis
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Lee Eun-Ji
Jang Young-Sun
Hong In-Kee
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Abstract
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This study assessed the inhibitory effects of lamb placenta peptide powder (LPP) on melanin production in animal models and B16F10 cells. The LPP contained 277.7 mg/100 g of free amino acids, which was 1.4 times higher than that of lamb placenta powder. The LPP significantly inhibited tyrosinase activity, the protein expression of whitening-related factors (PKA, CREB, MITF, TRP-1, and TRP-2), and the nitric oxide (NO) and, cAMP levels in the back skin tissue of UVB-irradiation treated mice. In B16F10 cells, melanin is derived from 3-isobutyl-1-methylxanthine, with LPP significantly inhibiting tyrosinase activity and melanogenesis. In addition, the protein expression of whitening-related factors was reduced. Moreover, the NO and cAMP levels were significantly reduced and, the production of glutathione increased. In conclusion, this study confirmed that LPP is a potential functional food material that can effectively inhibits melanin production in the skin.
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KEYWORD
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lamb placenta peptide powder, UVB, melanogenesis, melanin
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